Hepatitis C

Pathogenesis: Hepatitis C is the intimately common cause of chronic hepatitis in the world. The prevalence of hepatitis C virus infection is increasing normal every day. The World Health Organization estimates that much than cardinal million individuals throughout the world atomic number 18 infected with HCV. An estimated 1.8% of the macrocosm in the United States is positive for HCV antibodies; this pose cor acts to an estimated 3.9 million persons with HCV infection nationwide. (OShea, 2011). Hepatitis C is a spherical, enveloped, single-stranded ribonucleic acid virus be to family Flaviviridae. In persons who argon infected, HCV may throw approximately a trillion radical viral particles all(prenominal) day in a steady state of viral replication. There are at least 6 transmitted constitutions and more(prenominal) than 50 subtypes of the virus. The lifelike targets of HCV are hepatocytes and B lymphocytes. viral clearance is associated with the development and pe rseveration of strong virus- detail responses by cytotoxic T lymphocytes and helper T cells. Findings from more new-made studies suggest that 50% or more of the hepatocytes may be infected with HCV. Six major HCV genetic constitutions and legion(predicate) subtypes have been identified ground on molecular relatedness. molecular(a) differences between genotypes are relatively large.

genetic constitutions 1, 2, and 3 have a worldwide distribution, while genotypes 4, 5, and 6 are localized to specific geographic locations. Genotype 1 is the intimately common genotype in the United States. HCV genotype 1, especially 1b, does not respond to therapy as well as g! enotypes 2 and 3. Genotype 1 also may be associated with more severe liver-colored disease and a higher risk of hepatocellular carcinoma. Genotype 4 is the most prevalent genotype in Egypt, genotype 5 is engraft in South Africa, and genotype 6 is found in Southeast Asia. Currently, HCV is predominantly transmitted by percutaneous exposure to infected blood. In developed countries, most new HCV infections are related to intravenous drug abuse. The natural covering of blood...If you take to get a full essay, order it on our website: OrderCustomPaper.com

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